A surveillance study was undertaken to identify prominent �²-lactamase encoding\ngenes in 131 carbapenem non-susceptible gram-negative clinical isolates at a New\nYork City community hospital. KPC carbapenemases were detected in 89% of Enterobacteriaceae\nas well as additional TEM, SHV, and CTX-M class A enzymes. OXA-\n23 and OXA-24 were the prevalent class D carbapenemases identified in Acinetobacter\nspecies. One OXA-23 in M. morganii and one OXA-48 in K. pneumoniae were\nalso identified. Among class C �²-lactamases CMY, ACT/MIR, DHA, and FOX were\ndetected. The in vitro activity of ceftazidime-avibactam by E-test methodology was\ntested with minimal inhibitory concentrations (MIC) of â�¤3 �¼g/ml for 97.8% of all\nEnterobacteriaceae, MIC50/90 of 16/>256 �¼g/ml for carbapenem non-susceptible Acinetobacter\n, and 3/6 �¼g/ml for carbapenem non-susceptible Pseudomonas aeruginosa .\nPeriodic surveillance of isolates to characterize current and emerging �²-lactamase\ngenotypes present in local isolates may help identify outbreak situations, provide assistance\nto infection control and antibiotic stewardship programs, and potentially\nimprove patient outcomes.
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